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College of Medicine

Teaching

  • Pathology 205, Resident teaching

Clinical Interests

  • General chemistry
  • Point-of-care-testing
  • Quality assurance
  • Reference intervals
  • Endocrinology

Education

  • Fellow of the Canadian Academy of Clinical Biochemistry (FCACB)
  • Clinical Biochemistry Fellowship - University of Calgary Doctor of Philosophy
  • (Ph.D.) – University of Alberta; Master of Science (M. Sc.) – University of Lethbridge

Selected Publications

  • Zhang D, Zhao H, Kakodkar P, Webster D, Pearce T, Dokouhaki P, Wu F, Lewis C, Mostafa A. One transplant, two paths: PIRCHE-II and epitope mismatches reveal divergent routes to rejection. Human Immunology. 2025
  • Kline GA, Proctor D, Moledina N, Paul H, Robinson J, Lewis CW, Chin AC, Donovan L, Corenblum B, Rorstad O, Sadrzadeh HSM. Performance of the Siemens’ Thyroid Stimulating Immunoglobulin assay in the diagnosis of hyperthyroidism: prospective cohort study. Clinical Biochemistry. 2024
  • Lewis CW, Raizman J, Higgins V, Gifford JL, Symonds C, Kline G, Romney J, Doulla M, Huang C, Venner AA. Multidisciplinary approach to redefining thyroid hormone reference intervals with big data analysis. Clinical Biochemistry. 2024
  • Sokhi S, Lewis CW, Bukhari AB, Hadfield J, Xiao EJ, Fung J, Yoon YJ, Hsu WH, Gamper AM, Chan GK. Myt1 overexpression mediates resistance to cell cycle and DNA damage checkpoint kinase inhibitors. Frontiers in Cell and Developmental Biology. 2023
  • Ayoud AT, Nishiura N, Techima A, Elrefairy MA, Muslimin R, Do KM, Kodama T, Lewis CW, Chan G, Morita H, AraKawa. Bioinspired computational design of lankacidin derivatives for improvement in antitumor activity. Future Science. Vol 14. 2022
  • Lewis CW, Butorin Y, de Koning L, Paul H, Gifford JL, Venner AA, Sieden-Long I. Low partial pressure of oxygen causes significant and unrecognized under-recovery of glucose on blood gas analyzers. Clinical Biochemistry. Vol 111 (60-65). 2022
  • Muslimin R, Nishiura N, Techima A, Do MK, Kodama T, Morita H, Lewis CW, Chan G, Ayoub AT, Arakawa K. Chemoenzymatic synthesis, computational investigation, and antitumor activity of monocyclic lankacidin derivatives. Bioorganic & Medicinal Chemistry. Vol 53. 2021
  • Roy K, Lewis CW, Chan GK, and Bhattacharjee D. Automated classification of mitotic catastrophe by use of the centromere fragmentation morphology. Biochemistry and Cell Biology. Vol 99 Issue 2 (261-271). 2020
  • Lewis CW, Bukhari AB, Xiao EJ, Won-Shik C, Smith JD, Homola E, Mackey JR, Campbell SD, Gamper AM, and Chan GK. Cancer cells acquire resistance to the Wee1 inhibitor Adavosertib through the upregulation of Myt1. Cancer Research. Vol 79 Issue 23 (5971-5985). 2019
  • Bukhari AB, Lewis CW, Pearce JJ, Luong D, Chan GK, Gamper AM. Inhibiting Wee1 and ATR kinases produces tumor-selective synthetic lethality and suppresses metastasis. Journal of Clinical Investigations. Vol 129 Issue 2 (1329-1344). 2019
  • Lewis CW, Jin Z, Macdonald D, Wei WY, Qian XJ, Choi WS, Sun X, Chan GKT. Prolonged mitotic arrest induced by Wee1 inhibition sensitizes breast cancer cells to paclitaxel. Oncotarget. Vol 8 Issue 43 (73705-73722). 2017
  • Lewis CW, Golsteyn RM. Cancer cells that survive checkpoint adaptation contain micronuclei that harbour damaged DNA. Cell Cycle. Vol 15 Issue 22 (3131-3145). 2016
  • Ayoub AT, Ahmed R, Xiao J, Lewis CW, Tilli T, Arakawa K, Nindita Y, Chan G, Sun L, Glover M, Klobukowski M, Tuszynskiz J. Antitumor activity of lankacidin antibiotics is due to microtubule stabilization via a paclitaxel-like mechanism. Journal of Medicinal Chemistry. Vol 59 Issue 20 (9532-9540). 2016